Jay Cutler rallies Bears past Colin Kaepernick and 49ers, 28-20

— Down big, Jay Cutler kept his poise on the road while Colin Kaepernick struggled in prime time.

Cutler passed for three fourth-quarter touchdowns after much of Chicago’s starting defense went down, and the Bears beat the San Francisco 49ers, 28-20, Sunday night to spoil their Levi’s Stadium debut.

“We just kept plugging, we knew we had some good stuff,” Cutler said. “We just had to figure them out.”

Cutler threw three touchdown passes to Brandon Marshall, two in the wild fourth quarter, as Chicago erased a 13-point deficit and quieted the sellout crowd. Cutler threw for two scores in a 27-second span early in the final period, aided by the gutsy play of a backup cornerback.

Kyle Fuller made two late interceptions for the depleted Chicago secondary, and the first set up the go-ahead score.

“Just coming in here, working hard, it was a team win,” said Fuller, the Bears’ first-round pick in this year’s draft. “We are thankful for that and will keep on building.”

Kaepernick was hit with an unsportsmanlike-conduct penalty for “inappropriate language” following Fuller’s first big play. That gave the Bears first-and-goal on the three, and Cutler threw a three-yard touchdown pass to Martellus Bennett as the Bears went ahead, 21-20.

Kaepernick had three passes intercepted in all, and also lost a fumble and his cool, a far cry from his breakout start on the Monday night stage nearly two years ago in a rout of the Bears. Cutler sat out that night because of a concussion.

A sloppy game filled with 26 penalties — 16 by the 49ers — and a crazy collapse overshadowed the fanfare of the regular-season debut for the sparkling $1.2-billion stadium.

The Bears (1-1), in a stretch with six of eight games on the road, go home with some serious momentum despite injuries on both sides of the ball.

Five key defenders are hurt: cornerbacks Sherrick McManis (quadriceps) and Charles Tillman (triceps), defensive end Trevor Scott (foot), safety Chris Conte (shoulder) and defensive tackle Jeremiah Ratliff (concussion).

The 49ers (1-1) had a 17-7 halftime lead, but missed an opportunity to grab an early lead in the NFC West after the defending Super Bowl champion Seattle Seahawks lost earlier in the day at San Diego.

Michael Crabtree caught a touchdown pass on his 27th birthday and Frank Gore ran for a score but also had his 54-yard touchdown burst negated by Anquan Boldin’s costly holding penalty.

San Francisco tight ends Vance McDonald (knee) and Vernon Davis (ankle) were hurt as the 49ers lost a home opener for the first time under fourth-year Coach Jim Harbaugh.